The more I read the more I go fuzzy
Are Law and Wald aware of data from Framingham, which show that falling cholesterol concentrations are directly associated with an increased risk of coronary heart disease?3 Are they aware of research from Japan that shows a completely inverse relation between rising cholesterol concentrations and deaths from coronary heart disease?4 Hundreds of papers contradict the association between raised cholesterol concentrations and death from coronary heart disease.
Shestov in his lipid clinics study in Russia even showed an inverse relation, with higher rates of coronary heart disease in patients with hypocholesterolaemia. The Honolulu study shows that, in people older than 50, a low cholesterol concentration is by far the most important risk factor for premature death.5 Law and Wald did not show one curve relating to cholesterol lowering
Law and Wald are effectively suggesting that there is no non-dangerous blood pressure or cholesterol concentration and that, therefore, almost everyone in the Western world should be given some kind of drug treatment. This is dangerous nonsense, and we should not be afraid to say so.the J shaped curve of total mortality with 5.2 mmol/l at the bottom of that curve (figure).
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