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Conclusion
The HOT study does not provide sufficient evidence of the benefits of intensive treatment of blood pressure (that is, reducing diastolic pressures below 90 mmHg) in patients with hypertension. However, in the original sub-group analysis of the HOT study, which looked at the results in patients with diabetes, there are differences in the outcomes between treatment groups. Patients with diabetes in the lowest target blood pressure group had significantly lower rates of cardiovascular events. Total mortality was also decreased.
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