Diabetes new drugs
My dad's patients didn't get thalidomide - he had a rule about new drugs. If there wasn't major benefit don't use them till they have been out and about for several years - I can not remember how many. Worst pills Best pills recommends seven years.
Of course, even randomised controlled trials can be misleading. Carl Heneghan and colleagues call for caution in interpreting the results of the recently published diabetes reduction assessment with ramipril and rosiglitazone medication (DREAM) trial of drug treatments to prevent diabetes (p 764). The reported positive effect of rosiglitazone looks less good at three years, when the rate of all cardiovascular events was higher in the intervention group, and if rates of heart failure are taken into account. Like Lanou, they conclude that we might do better to focus attention on evaluating pragmatic lifestyle measures rather than expensive and potentially harmful drugs.
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