Nitrofurantoin toxicity

The pulmonary toxicity of nitrofurantoin should be considered when treatment is extended for ≥ 6 months, especially if the patient is elderly. Patients should be made aware of the possibility of pulmonary toxicity, and advised to report dyspnoea or persistent cough. If pulmonary reactions occur, nitrofurantoin should be immediately stopped. Although cessation may be followed by regression of symptoms, the resolution of pulmonary injury arising from long-term use may be incomplete.