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Showing posts with label Diabetes. Show all posts
Showing posts with label Diabetes. Show all posts

Thursday, August 09, 2007

Avandia Debacle

LinkScarcely two weeks after the Senate overwhelmingly passed legislation touted as a major fix of FDA’s failing effort to assure drug safety, The New England Journal of Medicine published an analysis linking the diabetes drug Avandia to a 40% increase in the risk of heart attack. This finding is especially troubling because people with diabetes are already at high risk of cardiovascular problems. A million diabetics are estimated to be current Avandia users in the U.S.

Se here for rest of article

Thursday, July 05, 2007

Diabetes and actos like drugs

David M. Nathan, M.D.
Worstpills bestpills has a do not use notice on these drugs. Subscription to their website is minimal. They look for what's wrong rather than what's right and good on them!! They have some recent stuf on actos and sibling meds.

Friday, June 15, 2007

A pile of guidelines from NZGG


NZGG


Population Screening for Colorectal Cancer


Prostate Cancer Screening in New Zealand



A Guideline for the Management of Heart Failure: health professionals guide



Assessment and Management of Cardiovascular Risk


New Zealand Cardiovascular Guidelines Handbook: Developed for Primary Care Practitioners


The Management of People with Atrial Fibrillation and Flutter


Management of Type 2 Diabetes



Guidelines for the Management of Heavy Menstrual Bleeding


Management of Dyspepsia and Heartburn



Depression: information for health practitioners



Guidelines for Medical Practitioners Using Sections 110 and 110A of the Mental Health (Compulsory Assessment and Treatment) Act 1992


Guidelines for the Use of Acetylcholinesterase Inhibitor Drugs in the Treatment of People with Alzheimer's Disease



Diagnosis and Management of Soft Tissue Knee Injuries: Internal Derangements


Diagnosis and Management of Soft Tissue Shoulder Injuries and Related Disorders



New Zealand Acute Low Back Pain Guide, incorporating the Guide to Assessing Psychosocial Yellow Flags in Acute Low Back Pain

Analysis of Chronic Fatigue Syndrome Guidelines

Traumatic Brain Injury: Diagnosis, Acute Management and Rehabilitation

Diagnosis and Treatment of Adult Asthma

Management of Asthma in Children aged 1-15 years

The COPD-X Plan: Australian and New Zealand Guidelines for the management of Chronic Obstructive Pulmonary Disease 2006

Guidelines for the Management of Genital Herpes in New Zealand

Hormone Replacement Therapy

How come these have come out black

Wednesday, June 13, 2007

From the lancet

Findings

Against the predictions of the linear logistic model, neither all-cause nor cardiovascular deaths depended on systolic blood pressure in a strictly increasing manner. The linear logistic model was rejected by the Framingham data. Instead, risk was independent of systolic blood pressure for all pressures lower than a threshold at the 70th percentile for a person of a given age and sex. Risk sharply increased with pressure higher than the 80th percentile. Since systolic blood pressure steadily increases with age, the threshold increases with age, but more rapidly in women than in men.

Intrepretation

The Framingham data contradict the concept that lower pressures imply lower risk and the idea that 140 mm Hg is a useful cut-off value for hypertension for all adults. There is an age-dependent and sex-dependent threshold for hypertension. A substantial proportion of the population who would currently be thought to be at increased risk are, therefore, at no increased risk.

Friday, June 01, 2007

glitazones - diabetes

Drug Avandia

Statement by Sidney Wolfe, MD, Director of Health Research Group at Public Citizen

The New England Journal of Medicine study just released showing a 43 percent increase in heart attacks in people using Avandia should come as no surprise either to the Food and Drug Administration (FDA) or to Glaxo. In animal studies done prior to its approval, one of the most constant findings was damage to the heart, and within the first six years of approval there have been 689 cases of heart failure reported to the FDA in patients using the drug. In addition, there have been reports of anemia which, along with heart failure, increases the risk for a heart attack.

other side effects
  • principal unwanted effects include weight gain (about 5%, or 3.5 kg over 6 months)
  • water retention and leg oedema (in about 5%)
  • dizziness, headache, fatigue, and hypoglycaemia (only when used in combination with a sulphonylurea) has also been reported with both drugs in combination therapy
  • other reported effects with pioglitazone include visual disturbances, arthralgia, impotence, flatulence, proteinuria, haematuria and with rosiglitazone, gastrointestinal disturbances, rash, paraesthesia, dyspnoea, rash, alopecia and thrombocytopaenia
  • since rosiglitazone and pioglitazone can cause fluid retention, which may exacerbate or precipitate heart failure, these drugs should be avoided in patients with any current, or history of heart failure - note that all patients taking either glitazone should be monitored for features of heart failure
  • macular oedema - cases of new onset and worsening macular oedema have been reported in patients treated with rosiglitazone. It has been reported that "in some cases, macular oedema resolved or improved following discontinuation of therapy and in one case macular odema resolved after dose reduction "(2)
  • cardiovascular risk - there has been evidence from a meta-analysis concerning the use of rosiglitazone and increased risk of myocardial infarction (3) - for more detail see linked item
Here is some debate about the heart attack issue


My thoughts - it's not that effective so why bother with it at all!!!

Friday, October 13, 2006

Diabetes new drugs

My dad's patients didn't get thalidomide - he had a rule about new drugs. If there wasn't major benefit don't use them till they have been out and about for several years - I can not remember how many. Worst pills Best pills recommends seven years.

Of course, even randomised controlled trials can be misleading. Carl Heneghan and colleagues call for caution in interpreting the results of the recently published diabetes reduction assessment with ramipril and rosiglitazone medication (DREAM) trial of drug treatments to prevent diabetes (p 764). The reported positive effect of rosiglitazone looks less good at three years, when the rate of all cardiovascular events was higher in the intervention group, and if rates of heart failure are taken into account. Like Lanou, they conclude that we might do better to focus attention on evaluating pragmatic lifestyle measures rather than expensive and potentially harmful drugs.

Tuesday, October 03, 2006

Diabetes

In that same issue of the BMJ there is an example of a similar piece of misinformation cited in fact by two separate authors, namely that patients with diabetes and no history of cardiac disease have a risk of cardiovascular (CV) events similar to non-diabetics with previous myocardial infarction. 1,2 This observation from an article published in 1998 (3) continues to be restated even though numerous subsequent articles have pointed out that this equivalence applies only to certain subgroups of diabetics such as those with multiple other risk factors, underlying renal disease, or longstanding diabetes at baseline. Among diabetics in general, the incidence of a CV event is only about 1/2 that of patients with a past infarction. In fact, in diabetics without other risk factors (4) or with normal coronary arteries at baseline (5) the risk of a CV event is not signficantly different from that of the general population.

Saturday, August 19, 2006

Guidelines - Managers love them!!

Tight glycaemic control reduces the risk of and slows the progression of microvascular and macrovascular complications. A stepped approach is recommended to lower and maintain HbA1c to as close to physiological levels as possible, preferably less than 7%, without hypoglycaemia.
The above comes from here. The New Zealand guidelines website. This website is a great source of information. I use it heaps. It has enabled me to get and keep reasonably up to speed. Many of those involved in developing these guidelines see them for what they - works in progress - not the final solution. However for many they are - the gospel. They are sourced in an evidence based way and so they must be as close to the truth as we can be for moment. There are some who say EBM - evidence based medicine - though based on sound principles, has become a religion in some people's hand, potentially dangerous to doctors and patients.

Take the information in the guideline above and compare it to the next two paragraphs which come from what seems like an impeccable source to me.
Tight glucose control did not prevent premature mortality or significantly reduce any clinically important diabetes-related complications.

In overweight patients treated with either insulin or sulfonylureas, there was no effect on diabetes-related complications, regardless of the degree of glucose control. (Click here to get full article)
Now I am not an academic or an expert on diabetes. I don't know how to sift B.S. from the good stuff. But the point is very few of us can. And we have all been burnt by what was the truth and now isn't. We have also been burnt by the opinion of experts.
In a recent analysis of review articles on the treatment of type 2 diabetes, we found that the experts writing them often did not tell us—the readers—the most important research evidence published in the past 25 years in the treatment of patients with type 2 diabetes.2 It's time to explore the value of experts and examine our reliance—or even addiction—to the pronouncements of experts.

Don't get me wrong I use the opinion of experts everyday. I couldn't function without them. And I check up on them too!!

In NZ the health managers and others living in airy fairy abstraction land may wonder why doctors aren't doing what's best for their patients, ie following their rules, ie guidelines to the letter. Well numero uno we aren't being paid as well as they are in the UK to be obedient robots. There they get paid 12 thousand pounds or so to audit their post heart attack patients for mild depression and then offer them counselling services that don't even exist. Don't believe me read NHS Blog Doc. He has some hilarious stories to tell. Click on him.

There are problems with guidelines. They are not necessarily best practice. They get it wrong sometimes. Even if they are on the mark they change. The truth is not static. Also there can be different interpretations of the evidence - see above. If a doctor is forced to prescribe against what he or she knows to be true, this is not good for their health or their future happiness. The sacrifice of integrity is a high price to pay.

Health managers have taken over the medical profession - well nearly. Guidelines are on the way to becoming rules. We can feeeeeel it coming. Payment and punishment based on guidelines. Obedience and a loss of integrity can have soul destroying outcomes. No wonder many doctors are not advising their kids to follow them into what is fast becoming a job - rather than a profession.

Doctors really do not want to be force fed and neither do many of their patients. Why should patients obey these guidelines? Really why should they. What is actually in it for them? 99 folk swallow a pill everyday for a year and get zip out of it. Doctors see and patients experience the side effects. Neither experience the benefits.

How long do you have to take BP pills for before you experience a benefit? You never do experience a benefit. Even if you are one of the lucky ones who would have had a stroke but don't have one, you can not know you would have had a stroke if you hadn't take the pill and so you have no experience of benefit. The doctors don't experience the benefit directly either. Yes your BP may be lower but so what - you maybe one of the unlucky ones that gets a stroke anyway. The benefits are theoretical as far as the individual and his doctor are concerned but the side effects are not.

His blood pressure maybe perfect but he has a cough, feels tired and has swollen legs - all caused by the the three different pills he is on. Having a normal blood pressure doesn't make him feel any better. So why should he persist? He knows doctors can be wrong. He knows folk are making money out of him. He's suspicious. He's seen his mate on ten different pills not doing very well. He wants no more pills thanks all the same doctor. Patient non compliance is a major factor. It's not just the doctors fault. And yes many doctors are non complaint too - especially when it comes their turn to take pills - many of them don't even check their own blood presssure.

There's another problem with guidelines - how things work in trials with motivated and relatively healthy patients and ambitious researchers/doctors is very different to the real world. Many trials are done on younger and fitter groups than coal face doctors deal with. An 80 year old diabetic with hypertension may have arthritis heart failure reflux and a whole pile of other complaints. By the time each condition is treated they are on a sack load of pills. Polypharmacy is not a good idea! It's bloody nuts unless a particular patient is highly motivated and well supported it just isn't going to happen. And anyway are the findings in that study relevant to this particular person?

The HDC , my personal bete noir, a government opinion generating organisation, that sits outside normal due process, passed judgement on me on a couple of issues. It took them three years. One of these issues was a dose of valium I prescribed. This ...... (words don't fail me.It's just what I want to say could land me in hot water) anyway this ........ decided I had used more than a therapeutic dose. How did she know this? She looked in New Ethicals. She blindly accepted what was in that book. She was wrong. Was there anyway of correcting her? Of course not. This opinion, garbage, still sits on my records.

In a few years time guidelines will be used this way too - they probably are already.

Bottom line any system that imposes from top down will in the end fail!! When the boys and girls at the coal face no longer love their work those at the top won't last very long - a couple of generations maybe. They will go out of fashion just like their dreams, visions, ideals, missions and so on. If they want monkeys that's what they will get.





Okay time to stop. I'll get back to the HDC again one day.

More on type 2 diabetes.

Started in 1977, the United Kingdom Prospective Diabetes Study was designed to determine whether glucose control decreases diabetes-related complications and increases life expectancy. A second arm of the study investigated the role of tighter control of blood pressure in patients with both diabetes and hypertension.The results in the following tables may surprise you.They come from this article. You can click on the three tables below to enlarge them.
More from the authors of the above tables
Blowing the whistle on review articles
Reading the rapid responses at the end of these articles is well worth it.


Then read this
The diabetes control and complications trial (DCCT) in type 1 diabetes and the UK prospective diabetes study (UKPDS) in type 2 diabetes showed that the lower the glycated haemoglobin achieved the lower the risk of microvascular complications.

And the truth is???

Myth Buster Review type 2 Diabetes

Read this article and keep in mind the present pressure on doctors to tightly control sugar levels in type 2 diabetics and the intense push to use ACE inhibitors in these patients with hypertension. It's stunning reading and fascinating to read the rapid responses at the end. This gives insight into how trends and fashions carry us along cheering for our cherished beliefs in face of evidence to the contrary.

Got to go for a walk