NNT - osteoporosis

What is the NNT to prevent an osteoporotic fracture using Risedronate or Aledronate? Similarly using calcium and vitamin D? Is it necessary to give calcium supplements as well as risedronate or aledronate?

Great website - here - non drug company funded too

another NNT

Dem bones

The use of an SSRI among persons aged 50 and older appears to be associated with an approximately two-fold increase in the risk of fragility fractures Richards, J.B., et al, Arch Intern Med 167:188, January 22, 2007

An increased risk of hip fractures with long-term use of PPIs among patients over the age of 50. Yang, Y.X., et al, JAMA 296(24):2947, December 27, 2006

Osteoporosis

Site maintained by Susan Ott, MD Associate ProfessorDepartment of MedicineUniversity of Washington. Osteoporosis and Bone Physiology .

She has a fracture risk calculator.

This site has no advertisements and is not funded by anyone but the lady herself.

Calcium plus vitamin D: Modest effects
Jackson RD. Calcium plus Vitamin D Supplementation and the Risk of Fractures. New Engl J Med 2006:354:669-83.
This study of 36,282 women from the Women's Health Initiative showed no significant reduction in fractures in those assigned to take supplements of calcium and vitamin D, but there was an increased risk of kidney stones. This news is not all that surprising because some previous studies did not show benefits of excess calcium in ordinary women. The findings of kidney stones suggest that calcium intake should not be greater than 1500mg/day.